{"id":134,"date":"2011-12-06T11:48:50","date_gmt":"2011-12-06T16:48:50","guid":{"rendered":"http:\/\/sites.biochem.umass.edu\/vierlinglab\/?page_id=134"},"modified":"2012-01-19T14:23:24","modified_gmt":"2012-01-19T19:23:24","slug":"shsps-in-big-packages-the-holey-soccer-ball-structure","status":"publish","type":"page","link":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/vierling-lab-reserach\/shsps-in-big-packages-the-holey-soccer-ball-structure\/","title":{"rendered":"sHsps in big packages &#8211; sHSP native structure"},"content":{"rendered":"<p><strong>sHsps in big packages &#8211; sHSP native structure<\/strong><br \/>\nAlthough sHSP\/\u03b1C monomers are relatively small, the majority of these proteins exist as oligomers of between 12 to &gt;48 subunits in their native state. The first solved structures of sHSP\/\u03b1C oligomers were those of the 24-subunit Hsp16.5 from the archaeon <em>Methanocaldococcus<\/em> <em>jannaschii, <\/em>(formerly classified within the<em> <\/em>genus <em>Methanococcus<\/em>) <em><\/em>and the eukaryotic dodecameric Hsp16.9 from <em>Triticum aestivum<\/em> (wheat), published by our group in collaboration with CHristine SLingsby (Birkebeck College, UK). These structures defined the architecture of the ACD, identified a dimeric substructure, and clarified the contacts required for oligomerization. Recently, additional structures of primarily the ACD have been determined from bacteria and metazoans, including human HspB5. Obtaining high resolution data for oligomeric forms of the metazoan proteins has been challenging because of the well-documented polydispersity of the oligomers.<\/p>\n<div>\n<hr align=\"left\" size=\"1\" width=\"33%\" \/>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>sHsps in big packages &#8211; sHSP native structure Although sHSP\/\u03b1C monomers are relatively small, the majority of these proteins exist as oligomers of between 12 to &gt;48 subunits in their native state. The first&#46;&#46;&#46;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":11,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-134","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/pages\/134","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/comments?post=134"}],"version-history":[{"count":6,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/pages\/134\/revisions"}],"predecessor-version":[{"id":686,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/pages\/134\/revisions\/686"}],"up":[{"embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/pages\/11"}],"wp:attachment":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/media?parent=134"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}