{"id":2282,"date":"2018-03-01T14:28:28","date_gmt":"2018-03-01T19:28:28","guid":{"rendered":"http:\/\/sites.biochem.umass.edu\/vierlinglab\/?p=2282"},"modified":"2018-03-01T14:32:13","modified_gmt":"2018-03-01T19:32:13","slug":"study-suggests-evolutionary-change-in-protein-function-respects-biophysical-principles","status":"publish","type":"post","link":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/2018\/03\/01\/study-suggests-evolutionary-change-in-protein-function-respects-biophysical-principles\/","title":{"rendered":"Study Suggests Evolutionary Change in Protein Function Respects Biophysical Principles"},"content":{"rendered":"<p>&#8220;AMHERST, Mass. \u2013 Some molecular biologists who study the proteins that regulate cell operations, including Elizabeth Vierling at the University of Massachusetts Amherst, do not confine their research to understanding the molecules\u2019 current roles. They also look deep into the proteins\u2019 evolutionary past to explore what structures have allowed proteins with new functions to develop in response to new needs.&#8221;\u00a0 <a href=\"http:\/\/www.umass.edu\/newsoffice\/article\/study-suggests-evolutionary-change-protein\">Click for the rest of the UMass Press Release.<\/a><\/p>\n<p><a href=\"http:\/\/science.sciencemag.org\/content\/359\/6378\/930\">For the scientific article:<\/a><\/p>\n<div class=\"highwire-cite-title media__headline__title\"><em><strong>Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions<\/strong><\/em><\/div>\n<p class=\"highwire-cite-authors byline\">By <span class=\"highwire-citation-authors\"><span class=\"highwire-citation-author first\">Georg K. A. Hochberg<\/span>, <span class=\"highwire-citation-author\">Dale A. Shepherd<\/span>, <span class=\"highwire-citation-author\">Erik G. Marklund<\/span>, <span class=\"highwire-citation-author\">Indu Santhanagoplan<\/span>, <span class=\"highwire-citation-author\">Matteo T. Degiacomi<\/span>, <span class=\"highwire-citation-author\">Arthur Laganowsky<\/span>, <span class=\"highwire-citation-author\">Timothy M. Allison<\/span>, <span class=\"highwire-citation-author\">Eman Basha<\/span>, <span class=\"highwire-citation-author\">Michael T. Marty<\/span>, <span class=\"highwire-citation-author\">Martin R. Galpin<\/span>, <span class=\"highwire-citation-author\">Weston B. Struwe<\/span>, <span class=\"highwire-citation-author\">Andrew J. Baldwin<\/span>, <span class=\"highwire-citation-author\">Elizabeth Vierling<\/span>, <span class=\"highwire-citation-author\">Justin L. P. Benesch<\/span><\/span><\/p>\n<p class=\"highwire-cite-metadata byline\"><em>Science<\/em>23 Feb 2018 : 930-935<\/p>\n<p>http:\/\/science.sciencemag.org\/content\/359\/6378\/930<\/p>\n<p><a href=\"http:\/\/sites.biochem.umass.edu\/vierlinglab\/2018\/03\/01\/study-suggests-evolutionary-change-in-protein-function-respects-biophysical-principles\/a-plant-protein-images\/\" rel=\"attachment wp-att-2283\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2283\" src=\"https:\/\/sites.biochem.umass.edu\/vierlinglab\/files\/2018\/03\/a-plant-protein-images.jpg\" alt=\"\" width=\"318\" height=\"159\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;AMHERST, Mass. \u2013 Some molecular biologists who study the proteins that regulate cell operations, including Elizabeth Vierling at the University of Massachusetts Amherst, do not confine their research to understanding the molecules\u2019 current roles.&#46;&#46;&#46;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2282","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/posts\/2282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/comments?post=2282"}],"version-history":[{"count":4,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/posts\/2282\/revisions"}],"predecessor-version":[{"id":2287,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/posts\/2282\/revisions\/2287"}],"wp:attachment":[{"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/media?parent=2282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/categories?post=2282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.biochem.umass.edu\/vierlinglab\/wp-json\/wp\/v2\/tags?post=2282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}