Publications

97. Williams RV, Guay KP, Hurlbut Lesk OA, Clerico EM, Hebert DN, Gierasch LM.
Insights into the interaction between UGGT, the gatekeeper of folding in the ER, and its partner, the selenoprotein SEP15. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34): e2315009121

96. Tax, G., K. P. Guay, L. Pantalone, M. Ceci, T. Soldà, C. J. Hitchman, J. C. Hill, S. Vasiljević,
A. Lia, C. P. Modenutti, K. R. Straatman, A. Santino, M. Molinari, N. Zitzmann, D. N. Hebert, P. Roversi and M. Trerotola (2024),
Rescue of secretion of rare-disease associated misfolded mutant glycoproteins in UGGT1 knock-out
mammalian cells. Traffic Jan;25(1):e12927. doi: 10.1111/tra.12927.

95. Canniff, N.P., J.B. Graham, K.P. Guay, D.A. Lubicki, S.J. Eyles, J.N. Rauch and D.N. Hebert (2023)
TTC17 is an endoplasmic reticulum resident TPR- containing adaptor protein, J. Biol. Chem.
299(12)105450

94. Guay, K.P., H. Ke, N.P. Canniff, G.T. George, S.J. Eyles, M. Mariappan, J.N. Contessa, A. Gershenson, L.M. Gierasch and D.N. Hebert (2023) ER chaperones use a protein folding and quality control glyco-code,
Molecular Cell 83(4524-4537)

93. Guay, K.P., R. Ibba, J.L. Kiappes, S. Vasiljevic, F. Boni, M. De Benedictis, I. Zeni, J.D. Le Cornu, M. Hensen, A.V. Chandran, A.L. Kantsadi, A.T. Caputo, J.I. Blanco Capurro, Y. Bayo, J.C. Hill, K. Hudson, A. Lia, J. Brun, C.P. Modenutti, S.G. Withers, M. Marti, E. Biasini, A. Santino, M. De Rosa, M. Milani, D.N. Hebert, N. Zitzmann and P. Roversi (2023)
A quinoline-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control
checkpoint, iScience, 26(10):107919

92. Guay, K.P., H. Ke, L. M. Gierasch, A. Gershenson and D.N. Hebert (2023) Monitoring the 
secretion and activity of alpha-1 antitrypsin in various mammalian cell types. Methods Mol
Biol.143-163

91. Canniff, N. P., K.P. Guay, and D.N. Hebert (2023) Carbohydrates Direct the Maturation and
Trafficking of Glycoproteins in the Secretory Pathway. In: Bradshaw Ralph A., Hart Gerald
W. and Stahl Philip D. (eds.) Encyclopedia of Cell Biology, Second Edition, vol. 4, pp. 320-
330. Oxford: Elsevier.

90. Guay, K.P., R.V. Williams and D.N. Hebert (2022) Calnexin reveals a sugar-free taste within
the lipid bilayer. EMBO J. 41(24):e113003. doi: 10.15252/embj.2022113003. Epub 2022
Nov 15. PMID: 36377534

89. Ke, H., K.P. Guay, T. R. Flotte, L. M. Gierasch, A. Gershenson and D.N. Hebert (2022)
Secretion of functional a1-antitrypsin is cell type dependent: implications for intramuscular
delivery for gene therapy. Proc. Natl. Acad. Sci. USA 119(31):e2206103119.
PMID: 35901208

88. Adams, B. M., N. P. Canniff, K. P. Guay and D. N. Hebert (2021) The role of ER chaperones
in protein folding and quality control. Progress in Molecular and Subcellular Biology:
Cellular Biology of the Endoplasmic Reticulum Editor Marek Michalak and Louis Agellon.
Springer Nature PMID: 34050861

87. Adams, B. M., N. P. Canniff, K. P. Guay, I.S.B. Larsen and D. N. Hebert (2020) Quantitative
glycoproteomics reveals substrate selectivity of the ER quality control sensors UGGT1 and
UGGT2. eLife e63997. PMID: 33320095 PMCID: PMC7771966

86. Daniels, R. and D. N. Hebert (2020) In support of simian polyomavirus 40 VP4 as a latter
expressed viroporin. mSphere. 5(2) e00187-20. PMID: 32188752

85. Graham, J. B., J. C. Sunryd, K. Mathavan, E, Weir, I.S.B. Larsen, A. Halim, H. Clausen, H.
Cousin, D. Alfandari, D. N. Hebert (2020) Endoplasmic reticulum transmembrane protein
TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic
gastrulation. Molecular Biology of the Cell 31(3):167-183. PMID: 31851597

84. Adams, B. M., H. Ke, L. M. Gierasch. A. Gershenson and D. N. Hebert (2019) Proper
secretion of the serpin antithrombin relies strictly on thiol-dependent quality control, J. Biol.
Chem. 294(50):18992-19011. PMID: 31662433

83. Graham, J. B., N. P. Canniff and D. N. Hebert (2019) TPR containing proteins control protein
organization and homeostasis in the endoplasmic reticulum. Critical Reviews in Molecular
and Cellular Biology 54(2):103-118.

82. Adams, B. M., M. E. Oster and D. N. Hebert (2019) Protein quality control in the
endoplasmic reticulum. The Protein Journal 38(3):317-329. PMC6589386

81. Lamriben, L., Oster ME, Tamura T, Tian W, Yang Z, Clausen H, and D. N. Hebert (2018)
EDEM1's mannosidase-like domain binds ERAD client proteins in a redox-sensitive manner
and possesses catalytic activity. J. Biol. Chem. 293(36):13932-13945.

80. Lamriben, L. and D. N. Hebert (2018) Activating and repressing IRE1 alpha: The Hsp47 and BiP
Tug of War, Mol. Cell 69(2):159-160.

79. Krishnan, B., L. Hedstrom, D. N. Hebert, L. M. Gierasch and A. Gershenson, (2018)
Expression and purification of active recombinant human Alpha-1 Antitrypsin (AAT) from Escherichia coli. Methods Mol Biol.
1639: 195-209.

78. Braakman, I., L. Lamriben, G. van Zadelhoff and D. N. Hebert (2017) Analysis of disulfide
bond formation overview. In Current protocols in protein science, J. E. Coligan, H.L. Ploegh,
J. A. Smith, D. W. Speicher and P.T. Wingfield, eds. (Brooklyn, NY: Greene Publ. Assoc. and
Wiley-Interscience.

77. Hebert, D. N., E. M. Clerico and L. M. Gierasch (2016) Division of labor: ER-resident BiP
co-chaperones match substrates to fates based on specific binding sequences. Mol. Cell
63(5):721-723.

76. Chandrasekhar, K., H. Ke, N. Wang, T. Goodwin, L.M. Gierasch, A. Gershenson, D. N.
Hebert (2016) Cellular folding pathway of a metastable serpin. Proc. Natl. Acad. Sci. USA
113(23):6484-9.

75. Lamriben, L., J. B. Graham, B. M. Adams, and D. N. Hebert, (2016) N-glycan based ER
molecular chaperone and protein quality control system: the calnexin binding cycle. Traffic.
17(4):308-26.

74. Molinari, M. and D. N. Hebert. (2015) Glycoprotein maturation and quality control,
Seminars in Cell and Developmental Biology, 41:70.

73. Tannous, A., G. B. Pisoni, D. N. Hebert and M. Molinari. (2015) N-linked sugar regulated
protein folding and quality control in the ER, Seminars in Cell and Developmental Biology,
41:79-89.

72. Tannous, A., N. Patel, T. Tamura, and D. N. Hebert. (2015) Reglucosylation by UDP-
glucose: glycoprotein glucosyltransferase 1 delays glycoprotein secretion but not
degradation. Molecular Biology of the Cell, 26(3):390-405.

71. Guiliano, D.B, H. Fussell, I. Lenart, E. Tsao, D. Nesbeth, A. Fletcher, E. C. Campbell, S.
Lynch, S. Santos, A. Cameron, G. Towers, P. Kellam, D. N. Hebert, K. Gould, S. J. Powis,
and A. N. Antoniou. (2014) EDEM1 targets misfolded HLA-B27 dimers for endoplasmic reticulum associated
degradation.

70. Hebert, D. N., L. Lamriben, E. T. Powers and J. W. Kelly. (2014) The intrinsic and extrinsic
effects of N-linked glycans on glycoproteostasis. Nature Chemical Biology, 10(11):902-910.

69. Sunryd, J.C., B. Cheon, J. B. Graham, K. M. Giorda, R. A. Fissore, D. N. Hebert. (2014)
TMTC1 and TMTC2 are novel endoplasmic reticulum TPR-containing adapter proteins
involved in calcium homeostasis. J. Biol. Chem. 289:16085-16099.

68. Sunryd, J. C., T. Tannous, L. Lamriben and D. N. Hebert (2014) Chaperones of the ERAD
pathway. In W. A. Houry (ed.), The Molecular Chaperones Interaction Networks in Protein
Folding and Degradation, Springer Press.

67. Giorda, K. M. and D. N. Hebert (2013) Viroporins customize host cells for efficient viral
propagation. DNA & Cell Biol. 2013 Oct;32(10):557-64.

66. Raghava, S., K. M. Giorda, F. B. Romano, A. P. Heuck and D. N. Hebert (2013) SV40 late
protein VP4 forms toroidal pores to disrupt membranes for viral release. Biochemistry. 2013
Jun 4;52(22):3939-48.

65. Giorda, K. M., S. Raghava, M. W. Zhang and D. N. Hebert (2013) The viroporin activity of
the minor structural proteins VP2 and VP3 is required for SV40 propagation. J. Biol. Chem.
288(4):2510-2520.

64. Braakman, I. and D. N. Hebert (2013) “Protein folding in the endoplasmic reticulum”, in
Ferro-Novick, S, R. Schekman, and T. Rapoport (ed.), Endoplasmic Reticulum Monograph,
Cold Spring Harbor Laboratory Press. May 1;5(5):a013201.

63. Hebert, D.N., K. D. Chandrasekhar and L. M. Gierasch (2012) You have to know when to
hold (or unfold) ‘em… [Preview] Molecular Cell 48(1):3-4.

62. Hebert, D. N. and M. Molinari (2012) Flagging and Docking: dual roles for N-glycans in
protein quality control and cellular proteostasis. Trends in Biochemical Sciences
37(10):404-410.

61. Hebert, D. N. (2012), An MBoC Favorite: Malectin: a novel carbohydrate-binding protein of
the endoplasmic reticulum and a candidate player in the early steps of protein N-
glycosylation. Molecular Biology of the Cell 23(12):2236.

60. Giorda, K. M., S. Raghava and D. N. Hebert (2012) The SV40 late viral protein VP4 disrupts
the nuclear envelope for viral release. Journal of Virology, 86(6):3180-92.

59. Hebert, D. N. (2012), "The ERAD Network", in Houry, W. (ed.), Protein Homeostasis, The
Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at
http://hstalks.com/?t=BL1423153-Hebert).

58. Tamura, T., J. H. Cormier and D. N. Hebert (2011) Characterization of the early EDEM1
maturation events and their functional implications. J. Biol. Chem., 286(28):24906-15.

57. Raghava, S., K. M. Giorda, F. B. Romano, A. P. Heuck and D. N. Hebert (2011) The SV40
late protein VP4 is a viroporin that forms pores to disrupt membranes viral release, PLoS
Pathogens, 7(6):e1002116.

56. Tamura, T., J. C. Sunryd and D. N. Hebert (2010) Sorting things out through ER quality
control, Molecular Membranes Biology, 27(8):412-427.

55. Pearse, B. R., T, Tamura, J. C. Sunryd, G. A. Grabowski, R. J. Kaufman and D. N. Hebert
(2010) The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an
obligate substrate, prosaposin, Journal of Cell Biology, 189:829-841.

54. Hebert, D.N., R. Bernasconi and M. Molinari (2010) ERAD substrates: which way out?
Seminar in Cell and Developmental Biology, 21:526-532.

53. Pearse, B. R. and D. N. Hebert (2010) Lectin chaperones help direct maturation of
glycoproteins in the endoplasmic reticulum, Biochimica et Biophysica Acta, 1803:684-693.

52. Cyr, D. M. and D. N. Hebert (2009) Protein Quality Control: A Meeting on Links Between
the Unfolded Protein Response and Disease, EMBO Reports, 10(11):1206-10.

51. Jejcic, A., R. Daniels, L. Goobar-Larsson, D. N. Hebert, and A. Vahlne (2009) Small
molecule targets Env for ER-associated protein degradation and inhibits HIV-1 propagation.
Journal of Virology 83(19):10075-84.

50. Hebert, D. N. and L. M. Gierasch (2009) The molecular dating game: an antibody heavy
chain hangs loose with a chaperone while waiting for its life partner. [Preview] Molecular
Cell 34:635-636.

49. Cormier, J. H., T. Tamura and D. N. Hebert (2009) EDEM1 recognition and delivery of
misfolded proteins to the SEL1L-containing ERAD complex. Molecular Cell 34:627-633.

48. Wang, N., E. J. Glidden, S. R. Murphy, B. R. Pearse and D. N. Hebert (2008) The
cotranslational maturation program for the type II membrane glycoprotein influenza
neuraminidase. J. Biol. Chem. 283:33826-33837.

47. Tamura, T., J. H. Cormier and D. N. Hebert (2008) Sweet bays of ERAD. Trends in
Biochemical Sciences 33:298-300.

46. Pearse B. R., L. Gabriel, N. Wang and D. N. Hebert (2008) A cell-based reglucosylation
assay demonstrates the role of GT1 in the quality control of a maturing glycoprotein.
Journal of Cell Biology 181:309-320.

45. Hebert, D. N. and M. Molinari (2007) In and out of the ER: protein folding, quality control
and degradation, and related human diseases. Physiology Reviews 87:1377-1408.

44. Hebert, D.N. (2007), "Glycoprotein Maturation and Quality Control in the Endoplasmic
Reticulum", in Michalak, M. (ed.), The Endoplasmic Reticulum: Fundamentals and Role in
Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London
(online at http://www.hstalks.com/?t=BL0121544-Hebert).

43. Daniels, R., D. Sadowicz and D. N. Hebert (2007) A very late viral protein triggers the lytic
release of SV40. PLoS Pathogens 3:e98, 0928-0938.

42. Pearse, B. R. and D. N. Hebert (2007) Calnexin, Calreticulin and their associated
oxidoreductase ERp57, The Enzymes, Vol. 25, “Molecular Machines involved in Protein
Transport across Cellular Membranes” Edited by R. E. Dalbey, C. Koehler and F. Tamanoi
for Academic Press/Elsevier.

41. Zuber, C., J. H Cormier, B. Guhl, R. Santimara, D. N. Hebert, and J. Roth (2007) EDEM1
reveals a novel quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites.
Proc. Natl. Acad. Sci. USA 104:4407-4412.

40. Daniels, R., N. M. Rusan, P. Wadsworth and D. N. Hebert (2006) SV40 VP2 and VP3
insertion into ER membranes is controlled by the capsid protein VP1: Implications for DNA
translocation out of the ER. Molecular Cell 24:955-966.

39. Pearse, B. R. and D. N. Hebert (2006) Co-translocational degradation: utilitarianism in the
ER stress response. [Preview] Molecular Cell 23:773-775.

38. Daniels, R., N. M. Rusan, A,-K. Wilbuer, L. C. Norkin, P. Wadsworth and D. N. Hebert
(2006) Simian Virus 40 late proteins possess lytic properties capable of permeabilizing cellular
membranes Journal of Virology 80:6575-87.

37. Wang, N. and D. N. Hebert (2006) Tyrosinase maturation through the mammalian secretory
pathway: bringing color to life. Pigment Cell Research 19:3-18.

36. Cormier, J. H., B. R. Pearse and D. N. Hebert (2005) Yos9p: A sweet-toothed bouncer of
the secretory pathway. [Preview] Molecular Cell 19:717-719.

35. Wang, N., R. Daniels and D. N. Hebert (2005) The co-translational maturation of the type I
membrane glycoprotein tyrosinase: the Hsp70 system hands off to the lectin-based
chaperone system. Molecular Biology of the Cell 16:3740-3752.

34. Hebert, D. N., S. C. Garman and M. Molinari (2005) The glycan code of the endoplasmic
reticulum: asparagine-linked carbohydrates as protein maturation and quality control tags."
Trends in Cell Biology 15:364-370.

33. Svedine, S., T. Wang, R. Halaban and D. N. Hebert (2004) Carbohydrates act as sorting determinants in
ER-associated degradation of tyrosinase Journal of Cell Science 117:2937-49.

32. Daniels, R., S. Svedine and D. N. Hebert (2004) N-Linked Carbohydrates Act as Lumenal Maturation
and Quality Control Protein Tags Cell Biochemistry and Biophysics 41:113-137.

31. Francis, E., N. Wang, H. Parag, R. Halaban and D. N. Hebert (2003) Tyrosinase maturation and oligomerization
in the endoplasmic reticulum requires a melanocyte-specific
factor. J. Biol. Chem. 278: 25607-17.

30. Hebert, D. N. (2003) Totally Sweet. [book review] Nat. Struct. Biol. 10:412.

29. Wang, T. and D. N. Hebert (2003) EDEM, a quality control receptor. [News and Views], Nature Structure Biology 10:319-321.

28. Schnell, D. J. and D. N. Hebert (2003) Protein translocons: Multi-functional mediators of
protein translocation across membranes. Cell 112:491-505.

27. Daniels, R., B. Kurowski, A. E. Johnson and D. N. Hebert (2003) N-linked glycans direct the
co-translational maturation of influenza hemagglutinin. Molecular Cell
11:79-90.

26. Halaban, R., Hebert, D. N., and Fisher, D. E. (2003) Biology of melanocytes. In: I. M.
Freedberg, A. Z. Eisen, K. Wolff, F. K. Austen, L. A. Goldsmith, and S. I. Katz (eds.),
Dermatology In General Medicine, 6 th edition, Vol. I, pp. 127-148. New York, NY:
McGraw Hill Medical Publishing.

25. Halaban, R., R. Patton, E. Cheng, S. Svedine, E. S. Trombetta, M. Wahl, S. Ariyan and D. N.
Hebert (2002) Abnormal acidification of Melanoma cells induces tyrosinase retention in
the early secretory pathway. J. Biol. Chem. 277: 14821-14828.

24. Halaban, R. E. Cheng and D. N. Hebert, (2002) Co-Expression of Wild Type Tyrosinase
Enhances Maturation of Temperature-Sensitive Tyrosinase Mutants, J. Invest
Dermatology 119:481-488.

23. Francis, E., R. Daniels and D. N. Hebert (2002) Analysis of Protein Folding and Oxidation in the Endoplasmic Reticulum In
Current Protocols in Cell Biology, J. S. Bonifacino, M. Dasso, J. B. Harford, J. Lippincott- Schwartz,
and K.M. Yamada, eds. NY: John Wiley & Sons Inc.

22. Újvári, A., R. Aron, T. Eisenhaure, E. Cheng, H. Parag, Y. Smicun, R. Halaban and D. N.
Hebert (2001) Translation rate of human tyrosinase determines its N-linked glycosylation level. J.
Biol. Chem. 276:5924-5931

21. Halaban, R., E. Cheng, S. Svedine, R. Aron, and D. N. Hebert, (2001) Proper folding and endoplasmic reticulum
to Golgi transport of tyrosinase are induced by its substrates, DOPA and tyrosine. J. Biol.
Chem. 276:11933-11938.

20. Halaban, R., S. Svedine, E. Cheng, Y. Smicun, R. Aron and D. N. Hebert (2000)
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative
albinism. Proc. Natl. Acad. Sci. USA 97:5889-5894.

19. Hebert, D. N. (1999) Protein unfolding, mitochondria offer a helping hand. Nature Structure
Biology 6:1084-1085.

18. Hebert, D. N., J.-X. Zhang and A. Helenius (1998) Protein folding and maturation in a cell- free
system. Biochem. and Cell Biol. 76: 867-873.

17. Hebert, D. N., J.-X. Zhang, W. Chen, B. Foellmer and A. Helenius (1997) The number and
location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin J. Cell Biol.
139:613-623.

16. Halaban, R., E. Chang, Y. Zhang, G. Moellmann, D. Henlon, M. Michalak, V. Setaluri and
D.N. Hebert (1997) Aberrant retention of tyrosinase in the endoplasmic reticulum mediates
accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of
amelanotic melanoma cells, Proc. Natl. Acad. Sci. USA 94: 6210-6215.

15. Helenius, A., E. S. Trombetta, D.N. Hebert and J.F. Simons (1997) Calnexin, calreticulin and
the folding of glycoproteins. Trends Cell Biology 7: 193-200.

14. Hebert, D. N., B. Foellmer and A. Helenius (1996) Calnexin and calreticulin promote
folding, delay oligomerization and suppress degradation of influenza hemagglutinin in
microsomes. EMBO J. 12: 2961-2968.

13. Braakman, I. and D. N. Hebert (1996) Disulfide (-SS-) bond formation overview. In Current
protocols in protein science, J. E. Coligan, H.L. Ploegh, J. A. Smith, D. W. Speicher and
P.T. Wingfield, eds. (Brooklyn, NY: Greene Publ. Assoc. and Wiley-Interscience.

12. Cannon, K.S., D.N. Hebert and A. Helenius (1996) Glycan dependent and independent
association of vesicular stomatitis virus G protein with calnexin. J. Biol. Chem. 271:
14280-14284.

11. Hebert, D. N., B. Foellmer and A. Helenius (1995) Glucose trimming and reglucosylation
determine glycoprotein association with calnexin in the endoplasmic reticulum. Cell 81: 425-
433.

10. Hebert, D.N., J.F. Simons, J.R. Peterson and A. Helenius (1995) Calnexin, calreticulin and
BiP/Kar2p in protein folding. Cold Spring Harbor Symposia on Quantitative Biology, LX
405-415.

9. Zottola, R. J., E. K. Cloherty, P. E. Coderre, A. Hansen, D. N. Hebert and A. Carruthers.
(1995) Glucose transporter function is controlled by transporter oligomeric structure: a
single, intramolecular disulfide promotes GLUT1 tetramerization. Biochemistry 34:9734-
9747.

8. Marquardt, T., D. N. Hebert and A. Helenius (1993) Folding of influenza hemagglutinin in
isolated endoplasmic reticulum derived microsomes. J. Biol. Chem. 268:19618-19625

7. Hebert, D. N. and A. Carruthers (1992) Glucose transporter oligomeric structure determines
transporter function: reversible redox-dependent interconversions of tetrameric and dimeric
GLUT1. J. Biol. Chem. 267:23829-23838.

6. Hebert, D. N. and A. Carruthers (1991) Cholate-solubilized erythrocyte glucose transporters
exist as a mixture of homodimers and homotetramers. Biochemistry 30:4654-4658.

5. Hebert, D. N. and A. Carruthers (1991) Uniporters and antiporters. Curr. Opin. Cell Biol., 3:702-709.

4. Pessino, A., D. N. Hebert, C. W. Woon, S. A. Harrison, B. M. Clancy, J. M. Buxton, A.
Carruthers and M. P. Czech (1991) Evidence that functional erythrocyte-type glucose
transporter are oligomers J. Biol. Chem. 266:20213-20217.

3. Helgerson, A. L., D. N. Hebert, S. Naderi and A. Carruthers (1989) Characterization of two
independent modes of action of ATP on human erythrocyte sugar transport. Biochemistry
28:6410-6417.

2. Carruthers, A., A. L. Helgerson, D. N. Hebert, R. E. Tefft, Jr., S. Naderi and D. L. Melchior
(1989) Effects of calcium, ATP and lipids on the human erythrocyte sugar transporter. Ann.
N.Y. Acad. Sci. 568:52-67.

1. Hebert, D. N. and A. Carruthers (1986) Direct evidence for ATP modulation of sugar
transport in human erythrocyte ghosts. J. Biol. Chem.  261:10093-10099.