Study Suggests Evolutionary Change in Protein Function Respects Biophysical Principles

“AMHERST, Mass. – Some molecular biologists who study the proteins that regulate cell operations, including Elizabeth Vierling at the University of Massachusetts Amherst, do not confine their research to understanding the molecules’ current roles. They also look deep into the proteins’ evolutionary past to explore what structures have allowed proteins with new functions to develop in response to new needs.”  Click for the rest of the UMass Press Release.

For the scientific article:

By Georg K. A. Hochberg, Dale A. Shepherd, Erik G. Marklund, Indu Santhanagoplan, Matteo T. Degiacomi, Arthur Laganowsky, Timothy M. Allison, Eman Basha, Michael T. Marty, Martin R. Galpin, Weston B. Struwe, Andrew J. Baldwin, Elizabeth Vierling, Justin L. P. Benesch

Science23 Feb 2018 : 930-935

http://science.sciencemag.org/content/359/6378/930